The relationship between condom use and herpes simplex virus acquisition.

نویسندگان

  • Anna Wald
  • Andria G M Langenberg
  • Elizabeth Krantz
  • John M Douglas
  • H Hunter Handsfield
  • Richard P DiCarlo
  • Adaora A Adimora
  • Allen E Izu
  • Rhoda Ashley Morrow
  • Lawrence Corey
چکیده

BACKGROUND Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition. OBJECTIVE To assess the relationship between condom use and acquisition of HSV-2 and HSV-1 among men and women. DESIGN Analysis of data collected as part of a clinical trial of an ineffective candidate vaccine for HSV-2. SETTING Sexually transmitted disease clinics. PARTICIPANTS Men and women at risk for HSV-2 acquisition, defined as having 4 or more sexual partners or having a sexually transmitted disease in the past year. MEASUREMENT Acquisition of HSV-2 and HSV-1 as measured by viral culture or change to positive HSV serostatus. RESULTS Of 1843 participants, 118 (6.4%) became infected with HSV-2. In multivariate analyses, participants reporting more frequent use of condoms were at lower risk for acquiring HSV-2 than participants who used condoms less frequently (hazard ratio, 0.74 [95% CI, 0.59 to 0.95]); categories of increasing condom use were 0% to 25%, 25% to 75%, and greater than 75% of sexual acts. Nineteen (2.9%) of 659 participants at risk for infection with HSV-1 became infected. No statistically significant association between condom use and infection with HSV-1 was found (hazard ratio, 0.79 [CI, 0.48 to 1.31]). LIMITATIONS Use of condoms was measured by self-report, and persons who used condoms may have differed from those who did not. CONCLUSIONS Consistent use of condoms is associated with lower rates of infection with HSV-2 and should be routinely recommended.

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عنوان ژورنال:
  • Annals of internal medicine

دوره 143 10  شماره 

صفحات  -

تاریخ انتشار 2005